shape may have a higher tendency to
fracture, or show a certain wear pattern
that allows earlier diagnosis and preventative action.
Anatomical data mining is the bridge be-
tween 3-D medical image data and the
design space for standard implants, pro-
viding orthopedic designers and engi-
neers with valuable parameters and
population models to develop and opti-
mize their products. Additional benefits
include reduced time to market and a po-
tential advantage with regulatory bodies
in justifying design choices such as shapes
and number of implant sizes. With
increasing regulatory requirements on
quality and lifetime of implants, and with
emerging markets in the BRIC nations
(Brazil, Russia, India and China) driving
the growth in the orthopedic industry,
population-based analysis, design and
optimization of implants is likely to
provide a competitive and marketing edge
for companies that use such technology. ;
1. Ogden CL, Fryar CD, Carroll MD, Fle-gal KM. Mean body weight, height, and body
mass index, United States 1960–2002. Advance data from vital and health statistics; no.
347 Hyattsville, Maryland: National Center
for Health Statistics, 2004.
2. Kwak D, Han S, Han CW, Han S. Resected femoral anthropometry for design of the
femoral component of the total knee prosthesis
in a Korean population, Anat Cell Biol. 43( 3):
252–259, September 2010.
3. Ho, W., Cheng, C., & Liau, J., Morpho-metrical Measurements of Resected Surface of
Femurs in Chinese Knees: Correlation to the
Sizing of Current Femoral Implants, The Knee,
13 (1), 12-14, 2006.
4. Dunteman, G.H., Principal Components
Analysis. Sage Publications, Newbury Park,
5. Plaster RL, Starkman KB, McGee J, The
Gender Solutions Natural-Knee Flex System
and Future Directions, Am J Orthop.
2010; 39( 6 suppl): 9-12, June 2010.
Koen Engelborghs is the business unit director
of Biomedical Engineering at Belgium-based
Materialise, a provider of biomedical software
solutions, consulting and additive manufactur-
ing services. Koen has a master's degree in en-
gineering and a Ph.D. cum laude in applied
mathematics. Prior to his current role, he served
in various roles at Materialise for 11 years,
including research developer, product manager,
research director, and technology and services
director, leading to a broad awareness of the
diverse applications and in-depth knowledge of
technologies related to image-based biomedical
engineering and biomedical applications of
additive manufacturing. Vinod Kaimal is the
business development manager for the Biomed-
ical Engineering business unit at Materialise.
He obtained his Ph.D. in biomedical engineer-
ing with a focus in medical imaging and also
holds a master’s degree in electrical engineer-
ing. He has co-authored multiple scientific
papers, white papers and a book chapter, and
has broad experience in biomedical engineering
related to imaging and medical devices.
In his current role, he is responsible for
developing partnerships with medical device
companies by providing advanced technologi-
cal solutions. He can be reached via email at
Figure 4: Variation of femur shape with size. The 3-D model in the center represents the population average. Notice how the femur neck
angle varies across the population. The neck angle increases with a rise in femur length, indicative of the effect of changes in loading conditions on geometry as a function of size. (Data generated by Materialise using a dataset of 40 Chinese femur scans.)
ODT • 59